Kinetic Parameter Inference in Metabolic Networks via Latent Space Exploration
Published:
We present a novel framework to interpret and control the latent spaces of generative neural network models for kinetic metabolic modeling. By perturbing structured latent spaces learned via REKINDLE or RENAISSANCE, our method generates new dynamic models with targeted properties such as specific response times, regulatory bottlenecks, or alternative physiologies, unlocking deeper insight and reusability across metabolic contexts.
